![]() ![]() Bone adapts its structure and strength to withstand mechanical loads, which are considered primarily to arise from muscle contractions. T he growth of bone and muscle is inseparably associated. ![]() The results do not support the view that muscle force drives the growth of bone size during puberty. Whereas TL ceased to increase 2 yr after menarche, tCSA, cCSA, tBMC, and mCSA continued to increase and were still significantly lower than adult values at the age of 18 yr (all p < 0.01). In contrast to our hypothesis, the growth velocity of mCSA peaked 1 yr later than that of tibial outer dimensions (TL and tCSA) and slightly earlier than tBMC. Seventy premenopausal adults, comprising a subset of the girl's mothers (mean age, 41.5 yr), were included for comparative purposes. The timings of the peak growth velocities for these variables were calculated. Growth trends as a function of time relative to menarche were determined from prepuberty to early adulthood for tibial length (TL), total cross-sectional area (tCSA), cortical CSA (cCSA), total BMC (tBMC), cortical volumetric BMD (cBMD), and muscle CSA (mCSA) in hierarchical models. Bone and muscle properties were measured using pQCT and DXA in 258 healthy girls at baseline (mean age, 11.2 yr) and 1-, 2-, 3–4- and 7-yr follow-up. This study aimed to test the hypothesis that the growth of muscle size precedes that of bone size (width and length) and mass during puberty. However, to date, no study has directly followed the growth of bone and muscle size through puberty and into adulthood. The growth of lean mass precedes that of bone mass, suggesting that muscle plays an important role in the growth of bone. ![]()
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March 2023
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